Transporters in Drug Development

The book describes methods and examples of in vitro characterization of single transporters in the intestines, liver and kidneys as well as characterization of substrate overlap between various transporters.

Transporters in Drug Development

Transporters in Drug Development

Transporters in Drug Development examines how membrane transporters can be dealt with in academic–industrial drug discovery and pharmaceutical development as well as from a regulatory perspective. The book describes methods and examples of in vitro characterization of single transporters in the intestines, liver and kidneys as well as characterization of substrate overlap between various transporters. Furthermore, probes and biomarkers are suggested for studies of the transporters’ impact on the pharmacokinetics of drug substrates/candidates interacting on transporters. The challenges of translating in vitro observed interaction of transporters into in vivo relevance are explored, and the book highlights perspectives of applying targeted proteomics and mechanistic modeling in this process.

More Books:

Transporters in Drug Development
Language: en
Pages: 317
Authors: Yuichi Sugiyama, Bente Steffansen
Categories: Medical
Type: BOOK - Published: 2013-09-16 - Publisher: Springer Science & Business Media

Transporters in Drug Development examines how membrane transporters can be dealt with in academic–industrial drug discovery and pharmaceutical development as well as from a regulatory perspective. The book describes methods and examples of in vitro characterization of single transporters in the intestines, liver and kidneys as well as characterization of
Transporters in Drug Discovery and Development
Language: en
Pages: 780
Authors: Yurong Lai
Categories: Medical
Type: BOOK - Published: 2014-08-22 - Publisher: Woodhead Publishing

Written by a leading researcher in the field, Transporters in Drug Discovery and Development provides a comprehensive and practical guide to drug transporter families that are the most important for drug discovery and development. It covers: an overview of transporter families and organ distribution; clinical relevant drug-drug interaction; clinical relevant
Membrane Transporters in Drug Discovery and Development
Language: en
Pages: 365
Authors: Qing Yan
Categories: Medical
Type: BOOK - Published: 2010-04-26 - Publisher: Humana

This text provides practical methodologies of the ongoing research on membrane transporters, considering applications of transporter technologies in drug discovery and development.
Drug Transporters
Language: en
Pages: 528
Authors: Guofeng You, Marilyn E. Morris, Binghe Wang
Categories: Medical
Type: BOOK - Published: 2014-09-02 - Publisher: John Wiley & Sons

This new edition discusses drug transporters that influence absorption, distribution, and elimination of drugs in the body. Retaining its predecessor's basic structure, the 2nd edition presents up-to-date information on drug transport families, principles of drug transport, and associated techniques for studying drug transport. New chapters cover multidrug and toxin extrusion
Membrane Transporters and Channels as Targets for Drugs
Language: en
Pages:
Authors: Graça Soveral, Cesare Indiveri
Categories: Medical
Type: BOOK - Published: 2020-01-03 - Publisher: Frontiers Media SA

Transporters and channels are membrane proteins that mediate the traffic of metabolites, water and ions across biological membranes. Membrane transport proteins are crucial to maintain homeostasis and assure cell survival upon intracellular or environmental stress. A failure of any of these transport systems may have dramatic consequences for cell function.

Popular All Time

Modern American Manners
The Old Farmer's Almanac 2021
The Action Heroine's Handbook
Daily Rituals
I Really Needed This Today
Rich Dad Poor Dad: What the Rich Teach Their Kids About Money - That the Poor and Middle Class Do Not! by Robert T. Kiyosaki (MaxHelp Workbooks)
100 Deadly Skills
If You Tell: A True Story of Murder, Family Secrets, and the Unbreakable Bond of Sisterhood by Gregg Olsen: Conversation Starters
2020 / 2021 ASVAB For Dummies with Online Practice
The Body Keeps the Score
Extreme Ownership
The Official DLAB Training Manual
Princeton Review SAT Premium Prep, 2021
5 Steps to a 5: AP World History: Modern 2020 Elite Student Edition
Romeo and Juliet (No Fear Shakespeare)
When We Believed in Mermaids: A Novel by Barbara O'Neal (Discussion Prompts)
Princeton Review AP World History: Modern Premium Prep, 2021
Princeton Review GED Test Prep, 2021

Recent Books:

Cyclopædia of Useful Arts, Mechanical and Chemical, Manufactures, Mining, and Engineering
Authors: Charles Tomlinson - Categories: Industrial arts - Published: 1854
Cyclopaedia of Useful Arts, Mechanical and Chemical, Manufactures, Mining and Engineering
Authors: Charles Tomlinson - Categories: Industrial arts - Published: 1868
Report of the National Science Board
Authors: Charles Tomlinson - Categories: Science - Published: 1977
Bulletin
Authors: Colorado School of Mines. Technical and Engineering Society - Categories: Engineering - Published: 1906